18F-Fluoroform: a 18F-trifluoromethylating agent for the synthesis of SCF218F-aromatic derivatives. Issue 42 (12th May 2017)

• Record Type: Journal Article
• Authors: Carbonnel, Elodie; Besset, Tatiana; Poisson, Thomas; Labar, Daniel; Pannecoucke, Xavier; Jubault, Philippe
• Is Part Of: Chemical communications. Volume 53:Issue 42(2017)
• Page Start: 5706
• Page End: 5709
• Publication Date: 2017-05-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc02652h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A new protocol for the synthesis of SCF2 18 F-aromatic derivatives from 18 F-fluoroform is described. Abstract : Herein the synthesis of various SCF2 18 F-containing derivatives is reported by a transition metal-free process. By using HCF2 18 F, readily generated from a bench-stable difluoromethyl sulfonium salt, various aromatic disulfides were easily converted into the desired radiolabelled trifluoromethylthiolated compounds in the presence of a base. This protocol allowed the formation of the SCF2 18 F-containing aromatic derivatives in good to excellent radiochemical yields. This process was also extended to the corresponding selenium derivative.