Cell biology in China: Focusing on the lysosome. (2nd May 2017)

• Record Type: Journal Article
• Authors: Yang, Chonglin; Wang, Xiaochen
• Is Part Of: Traffic. Volume 18:Number 6(2017)
• Page Start: 348
• Page End: 357
• Publication Date: 2017-05-02
• Subjects: autophagy‐lysosome pathway -- biogenesis -- cell death -- endo‐lysosomal trafficking -- lysosome secretion -- lysosomes -- membrane integrity -- signaling; Biological transport -- Periodicals; 571.6
• DOI: 10.1111/tra.12483
• Languages: English
• ISSNs: 1398-9219

Abstract

Abstract : The view that lysosomes are merely the recycling bins of the cell has changed greatly during recent years. Lysosomes are now known to play a central role in signal transduction, cellular adaptation, plasma membrane repair, immune responses and many other fundamental cellular processes. In conjunction with the seminal discoveries made by international colleagues, many important questions regarding lysosomes are being addressed by Chinese scientists. In this review, we briefly summarize recent exciting findings in China on lysosomal signaling, biogenesis, integrity and physiological functions. Abstract : Lysosomes maintain cell homeostasis, serve as signaling centers to integrate metabolism with cellular clearance, and are involved in many fundamental cellular processes such as plasma membrane repair, immune responses and cell death. This review summarizes recent exciting findings made by Chinese scientists on the biogenesis, integrity maintenance and physiological function of lysosomes.