Secondary cutaneous peripheral T‐cell lymphoma, unspecified, with generalized benign‐looking dermatitis: a possibly distinct peripheral T‐cell lymphoma. (27th February 2017)

• Record Type: Journal Article
• Authors: Lee, Woo Jin; Kang, Hyun Ji; Won, Chong Hyun; Chang, Sung Eun; Choi, Jee Ho; Lee, Mi Woo
• Is Part Of: International journal of dermatology. Volume 56:Number 6(2017)
• Page Start: 617
• Page End: 622
• Publication Date: 2017-02-27
• Subjects: Dermatology -- Periodicals; 616.5
• DOI: 10.1111/ijd.13493
• Languages: English
• ISSNs: 0011-9059

Abstract

Abstract: Background: Cutaneous lymphomas are a heterogeneous group of tumors with various clinical manifestations, histological features, and prognoses. Methods: Among 425 cases of cutaneous lymphoma, we describe eight cases of peripheral T‐cell lymphoma, unspecified, presenting with generalized benign‐looking dermatitis. Results: Our case series included eight cases of secondary cutaneous peripheral T‐cell lymphoma, unspecified. The observed clinical morphology features included drug eruption‐like generalized morbilliform maculopatches in two cases, generalized folliculitis‐like papules in two cases, and generalized eczematous dermatitis‐like papules and patches in four cases. Histopathological examination demonstrated tumor cell infiltrates of mainly atypical, small‐to‐medium lymphoid cells that were perivascularly or periadnexally distributed throughout the dermis. Immunohistochemical staining results for CD2, CD3, CD4, and CD8 revealed that the tumor cells were T‐cells. Conclusion: This collection of cases and literature review emphasizes the need for clinical suspicion of peripheral T‐cell lymphoma, unspecified, in the differential diagnosis of adult patients with refractory eczematous or benign‐looking skin lesions.