Hand‐Ground Nanoscale ZnII‐Based Coordination Polymers Derived from NSAIDs: Cell Migration Inhibition of Human Breast Cancer Cells1. Issue 24 (12th April 2017)

• Record Type: Journal Article
• Authors: Paul, Mithun; Sarkar, Koushik; Deb, Jolly; Dastidar, Parthasarathi
• Is Part Of: Chemistry. Volume 23:Issue 24(2017)
• Page Start: 5736
• Page End: 5747
• Publication Date: 2017-04-12
• Subjects: biological activity -- cytotoxicity -- drug delivery -- imaging agents -- polymers; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201605674
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Increased levels of intracellular prostaglandin E2 (PGE2 ) have been linked with the unregulated cancer cell migration that often leads to metastasis. Non‐steroidal anti‐inflammatory drugs (NSAIDs) are known inhibitors of cyclooxygenase (COX) enzymes, which are responsible for the increased PGE2 concentration in inflamed as well as cancer cells. Here, we demonstrate that NSAID‐derived Zn II ‐based coordination polymers are able to inhibit cell migration of human breast cancer cells. Various NSAIDs were anchored to a series of 1D Zn II coordination polymers through carboxylate–Zn coordination, and these structures were fully characterized by single‐crystal X‐ray diffraction. Hand grinding in a pestle and mortar resulted in the first reported example of nanoscale coordination polymers that were suitable for biological studies. Two such hand‐ground nanoscale coordination polymersNCP1 a andNCP2 a, which contained naproxen (a well‐studied NSAID), were successfully internalized by the human breast cancer cells MDA‐MB‐231, as was evident from cellular imaging by using a fluorescence microscope. They were able to kill the cancer cells (MTT assay) more efficiently than the corresponding mother drug naproxen, and most importantly, they significantly inhibited cancer cell migration thereby displaying anticancer activity. Abstract : Stopped in their tracks : Non‐steroidal‐anti‐inflammatory‐drug‐based Zn II coordination polymers are found to inhibit migration of the human breast cancer cell line MDA‐MB‐231 (see figure). The NSAIDs were anchored to a series of 1D Zn II coordination polymers through carboxylate–Zn coordination. Hand grinding in a pestle and mortar resulted in nanoscale coordination polymers that were suitable for biological studies.