53BP1 is a novel regulator of angiogenesis in breast cancer. Issue 11 (5th September 2013)
- Record Type:
- Journal Article
- Title:
- 53BP1 is a novel regulator of angiogenesis in breast cancer. Issue 11 (5th September 2013)
- Main Title:
- 53BP1 is a novel regulator of angiogenesis in breast cancer
- Authors:
- Li, Xiaoyan
Kong, Xiangnan
Wang, Yang
Yang, Qifeng - Abstract:
- Abstract : In our previous study, we found that 53BP1 was a tumor suppressor and was associated with prognosis in breast cancer. However, little is known about its role in angiogenesis. In the present study, we aimed to reveal the role of 53BP1 in angiogenesis of breast cancer. With RNA interference and ectopic expression strategies to elucidate the detailed function of 53BP1 in angiogenesis, we observed that ectopic expression of 53BP1 inhibited cellular angiogenesis and 53BP1 RNA interference led to an increase in angiogenesis both in vitro and in vivo . In clinical breast cancer samples, 53BP1 was inversely correlated with CD31, MMP‐2 and MMP‐9 by immunohistochemistry analysis. Furthermore, we showed that the Akt pathway was involved in the antiangiogenesis function of 53BP1 . Overall, our findings demonstrate that 53BP1 plays a vital role in inhibiting angiogenesis. These findings suggest that 53BP1 might provide a viable target therapy for breast cancer.
- Is Part Of:
- Cancer science. Volume 104:Issue 11(2013:Nov.)
- Journal:
- Cancer science
- Issue:
- Volume 104:Issue 11(2013:Nov.)
- Issue Display:
- Volume 104, Issue 11 (2013)
- Year:
- 2013
- Volume:
- 104
- Issue:
- 11
- Issue Sort Value:
- 2013-0104-0011-0000
- Page Start:
- 1420
- Page End:
- 1426
- Publication Date:
- 2013-09-05
- Subjects:
- Cancer -- Periodicals
Neoplasms -- Periodicals
Research -- Periodicals
Electronic journals
616.994005 - Journal URLs:
- http://firstsearch.oclc.org ↗
http://firstsearch.oclc.org/journal=1347-9032;screen=info;ECOIP ↗
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1349-7006 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1111/cas.12247 ↗
- Languages:
- English
- ISSNs:
- 1347-9032
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3046.603000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 1931.xml