Questionnaire to assess quality of life in patients with breast cancer – Validation of the Chinese version of the EORTC QLQ-BR 53. (April 2017)

• Record Type: Journal Article
• Authors: Zhang, Zhen; Zhang, Xian; Wei, Ling; Lin, Yunshou; Wu, Dongwen; Xie, Shumin; Yue, Lin; Tian, Jingru; Zhang, Yu; Song, Qijun; Woo, Stephenie Mu-Lian; Miller, Adam R.; Luo, Le; Zhang, Lei
• Is Part Of: Breast. Volume 32(2017)
• Page Start: 87
• Page End: 92
• Publication Date: 2017-04
• Subjects: Breast cancer -- Quality of life -- EORTC QLQ-BR53 -- Validation; Breast -- Diseases -- Periodicals; Breast -- Tumors -- Periodicals; Breast -- Periodicals; Electronic journals; Periodicals; 616
• DOI: 10.1016/j.breast.2016.12.019
• Languages: English
• ISSNs: 0960-9776

Abstract

Abstract: Purpose: To evaluate the reliability and validity of the Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Breast Cancer (EORTC QLQ-BR53) questionnaire firstly in north of China. Methods: A total of 294 outpatients with breast cancer in Tianjin Cancer Institution and Hospital from November 2014 to August 2015 were enrolled in this study. All patients self-administered the EORTC QLQ-BR25 and the Short Form 36 Health Survey (SF-36). The Eastern Cooperative Oncology Group (ECOG) scoring was performed to evaluate scores. Internal consistency reliability was determined by Cronbach's α coefficient for each dimension, with a Cronbach's α coefficient ≥0.7 considered to be statistically significant. Results: A satisfactory internal consistency reliability for most multi-item scales was confirmed, as Cronbach's α coefficients were close or greater than 0.7 except for breast symptoms (0.615). Multiple-trait scaling analysis demonstrated a good convergent and divergent validity of EORTC QLQ-BR53. Using SF-36 as a reference standard to evaluate the dimensions of EORTC QLQ-BR53, most items in EORTC QLQ-BR53 possessed a favorable correlation with its own dimension (r > 0.4). A statistically significant difference was discovered in dimension scores between patients grouped by ECOG scores except for individual dimensions. Conclusions: The Chinese version of EORTC QLQ-BR53 is a reliable and valid instrument for measuring the quality of life among Chinese patients with breast cancer. Highlights: As for breast cancer, China's proportional contribution to global rates is increasing rapidly. To evaluate the reliability and validity of the Chinese version of EORTC QLQ-BR53 questionnaire firstly in North China. There are high variances of cancer morbidity in different regions within China. EORTC QLQ-BR53 is proved suitable to serve as a QoL measurement instrument for patients with breast cancer in China.