Water‐Soluble N‐Heterocyclic Carbene‐Protected Gold Nanoparticles: Size‐Controlled Synthesis, Stability, and Optical Properties. Issue 22 (13th April 2017)

• Record Type: Journal Article
• Authors: Salorinne, Kirsi; Man, Renee W. Y.; Li, Chien‐Hung; Taki, Masayasu; Nambo, Masakazu; Crudden, Cathleen M.
• Is Part Of: Angewandte Chemie international edition. Volume 56:Issue 22(2017)
• Page Start: 6198
• Page End: 6202
• Publication Date: 2017-04-13
• Subjects: gold nanoparticles -- N-heterocyclic carbenes -- photoacoustic effect -- stability -- water solubility; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201701605
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: NHC‐Au I complexes were used to prepare stable, water‐soluble, NHC‐protected gold nanoparticles. The water‐soluble, charged nature of the nanoparticles permitted analysis by polyacrylamide gel electrophoresis (PAGE), which showed that the nanoparticles were highly monodisperse, with tunable core diameters between 2.0 and 3.3 nm depending on the synthesis conditions. Temporal, thermal, and chemical stability of the nanoparticles were determined to be high. Treatment with thiols caused etching of the particles after 24 h; however larger plasmonic particles showed greater resistance to thiol treatment. These water‐soluble, bio‐compatible nanoparticles are promising candidates for use in photoacoustic imaging, with even the smallest nanoparticles giving reliable photoacoustic signals. Abstract : Goldwasser : Water‐soluble, NHC‐functionalized Au nanoparticles (NPs) with tunable core diameters between 2.0 and 3.3 nm were prepared from molecular precursors. Temporal and chemical stability of the NPs were high, with aqueous stability of more than two months. However, exposure to thiols results in etching. All of the NPs tested gave reliable photoacoustic signals that scaled with NP concentration.