Pirfenidone: A Potential New Therapy for Restrictive Allograft Syndrome?. Issue 11 (18th September 2013)

• Record Type: Journal Article
• Authors: Vos, R.; Verleden, S. E.; Ruttens, D.; Vandermeulen, E.; Yserbyt, J.; Dupont, L. J.; Van Raemdonck, D. E.; De Raedt, N.; Gheysens, O.; De Jong, P. A.; Verleden, G. M.; Vanaudenaerde, B. M.
• Is Part Of: American journal of transplantation. Volume 13:Issue 11(2013)
• Page Start: 3035
• Page End: 3040
• Publication Date: 2013-09-18
• Subjects: Fibrosis -- lung transplantation -- pirfenidone -- restrictive allograft syndrome; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.12474
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : This case report describes the evolution of pulmonary function findings (FVC, FEV1 and TLC) and CT features with pirfenidone treatment for restrictive allograft syndrome following lung transplantation. Furthermore, we herein report hypermetabolic activity on 18 F‐FDG PET imaging in this setting, which could indicate active fibroproliferation and pleuroparenchymal remodeling. These findings may warrant further investigation. Abstract : The authors report on the use of pirfenidone to treat a patient with restrictive allograft syndrome after lung transplantation.