Intramolecular Direct Arylation of 1, 3‐Diketone‐Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives. Issue 9 (20th March 2017)

• Record Type: Journal Article
• Authors: Muimhneacháin, Eoin Ó; Pardo, Leticia M.; Bateman, Lorraine M.; Rao Khandavilli, U. B.; Lawrence, Simon E.; McGlacken, Gerard P.
• Is Part Of: Advanced synthesis & catalysis. Volume 359:Issue 9(2017)
• Page Start: 1529
• Page End: 1534
• Publication Date: 2017-03-20
• Subjects: direct arylation -- isochromenes -- isotopic scrambling -- Jeffery conditions -- palladium; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201700062
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A synthesis of tricyclic oxoisochromene derivatives via an intramolecular direct arylation of cycloalkyl‐1, 3‐diketone‐derived α, β‐unsaturated ketone substrates is described. Interesting mechanistic insight has been gathered, based on deuterium migration studies, induced by palladium (Pd). Abstract :