Synthesis of Complex Phenols Enabled by a Rationally Designed Hydroxide Surrogate. (24th March 2017)
- Record Type:
- Journal Article
- Title:
- Synthesis of Complex Phenols Enabled by a Rationally Designed Hydroxide Surrogate. (24th March 2017)
- Main Title:
- Synthesis of Complex Phenols Enabled by a Rationally Designed Hydroxide Surrogate
- Authors:
- Fier, Patrick S.
Maloney, Kevin M. - Abstract:
- Abstract: The conversion of aryl halides to phenols under mild reaction conditions is a longstanding and formidable challenge in organic chemistry. Herein, we report the rational design of a broadly applicable Pd‐catalyzed method to prepare phenols with benzaldehyde oxime as a hydroxide surrogate. These reactions occur under mildly basic conditions and enable the late‐stage hydroxylation of several functionally‐dense drug‐like aryl halides.
- Is Part Of:
- Angewandte Chemie. Volume 129:Number 16(2017)
- Journal:
- Angewandte Chemie
- Issue:
- Volume 129:Number 16(2017)
- Issue Display:
- Volume 129, Issue 16 (2017)
- Year:
- 2017
- Volume:
- 129
- Issue:
- 16
- Issue Sort Value:
- 2017-0129-0016-0000
- Page Start:
- 4549
- Page End:
- 4553
- Publication Date:
- 2017-03-24
- Subjects:
- Hydroxylierungen -- Kreuzkupplungen -- Medizinische Chemie -- Palladium -- Phenole
Chemistry -- Periodicals
540 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/ange.201700244 ↗
- Languages:
- English
- ISSNs:
- 0044-8249
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0902.000000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 472.xml