Lactate Detection in Tumor Cell Cultures Using Organic Transistor Circuits. Issue 13 (30th January 2017)

• Record Type: Journal Article
• Authors: Braendlein, Marcel; Pappa, Anna‐Maria; Ferro, Marc; Lopresti, Alexia; Acquaviva, Claire; Mamessier, Emilie; Malliaras, George G.; Owens, Róisín M.
• Is Part Of: Advanced materials. Volume 29:Issue 13(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-01-30
• Subjects: organic electrochemical transistor -- poly(3, 4‐ethylenedioxythiophene):poly(styrene sulfonate) -- tumor cell cultures -- Warburg effect -- Wheatstone bridge circuit; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201605744
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : A biosensing platform based on an organic transistor circuit for metabolite detection in highly complex biological media is introduced. The sensor circuit provides inherent background subtraction allowing for highly specific, sensitive lactate detection in tumor cell cultures. The proposed sensing platform paves the way toward rapid, label‐free, and cost‐effective clinically relevant in vitro diagnostic tools.