Synthetic strategies toward the synthesis of enoxacin-, levofloxacin-, and gatifloxacin-based compounds: A review. Issue 11 (3rd June 2017)

• Record Type: Journal Article
• Authors: Zahoor, Ameer Fawad; Yousaf, Muhammad; Siddique, Rabia; Ahmad, Sajjad; Naqvi, Syed Ali Raza; Rizvi, Sayyad Muhammad Ali
• Is Part Of: Synthetic communications. Volume 47:Issue 11(2017)
• Page Start: 1021
• Page End: 1039
• Publication Date: 2017-06-03
• Subjects: Antibacterial activity -- enoxacin -- fluoroquinolones -- gatifloxacin -- levofloxacin; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2017.1300921
• Languages: English
• ISSNs: 0039-7911

Abstract

ABSTRACT: Enoxacin, levofloxacin, and gatifloxacin represent one of the most important prerogative scaffolds in drug development. They possess broad spectrum antimicrobial and anti-inflammatory activities. They inhibit bacterial growth by blocking their topoisomerase enzyme which is necessary for the proper functioning of bacterial DNA. In this article, we have reviewed the synthetic approaches involved in the synthesis of derivatives of enoxacin, levofloxacin, and gatifloxacin. GRAPHICAL ABSTRACT: