A colloidally stable water dispersion of Ni nanowires as an efficient T2-MRI contrast agent. Issue 18 (18th April 2017)

• Record Type: Journal Article
• Authors: Bañobre-López, Manuel; Bran, Cristina; Rodríguez-Abreu, Carlos; Gallo, Juan; Vázquez, Manuel; Rivas, José
• Is Part Of: Journal of materials chemistry. Volume 5:Issue 18(2017)
• Page Start: 3338
• Page End: 3347
• Publication Date: 2017-04-18
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c7tb00574a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A colloidally stable dispersion of anisotropic Ni nanowires in water has been achieved showing good performance as a T 2 -contrast agent in MRI. Abstract : A colloidally stable dispersion of anisotropic Ni nanowires in water has been achieved showing good performance as a T 2 -contrast agent in magnetic resonance imaging (MRI). A wet chemistry approach has been developed that renders water dispersible Ni nanowires of controlled size. Firstly, an array of Ni/Au multilayer nanowires of tailored dimensions was synthesized by pulsed electrodeposition within a porous alumina template in a three-electrode cell at room-temperature. Then, Ni/Au multilayer nanowires were released from the template followed by the isolation of the Ni segments through a two-step acidic etching, ending up with a colloidally stable dispersion of poly-acrylic acid (PAA)-coated Ni nanowires in water solution. The PAA-coated Ni nanowires have been morphologically and structurally characterized by scanning and transmission electron microscopy (SEM, TEM, respectively), whereas their ferromagnetic properties were studied using a SQUID-magnetometer. Importantly, relaxivity properties (transversal relaxivity, r 2 ) indicated good performance of PAA-coated Ni nanowires as a T 2 -contrast agent at 1.41 T and body temperature, with values as large as those of commercial contrast agents based on iron oxide nanoparticles. MRI phantom imaging at clinical fields of 3 T confirmed the dark contrast effect of PAA-coated Ni nanowires, as compared to a water control, which opens a new window of opportunities for anisotropic metal nanostructures as contrast agents in MRI applications.