Synthesis, biological evaluation and molecular docking of spirofurochromanone derivatives as anti-inflammatory and antioxidant agents. Issue 41 (12th May 2017)

• Record Type: Journal Article
• Authors: Ashok, D.; Madhuri, E. V. L.; Sarasija, M.; Sree Kanth, S.; Vijjulatha, M.; Alaparthi, Malini D.; Sagurthi, S. R.
• Is Part Of: RSC advances. Volume 7:Issue 41(2017)
• Page Start: 25710
• Page End: 25724
• Publication Date: 2017-05-12
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra01550j
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A series of 2′-substituted-3′-methylspiro[cyclohexane-1, 7′-furo[3, 2- g ]chroman]-5′(7′ H )-one, 5a–i and7a–u have been synthesized using an eco-friendly approach with good anti-inflammatory and antioxidant activity. Abstract : A series of 2′-substituted-3′-methylspiro[cyclohexane-1, 7′-furo[3, 2- g ]chroman]-5′(7′ H )-one, 5a–i and7a–u have been synthesized using an eco-friendly approach to attain good yields in a shorter reaction time. The structures of novel compounds were characterized by IR, 1 H NMR, 13 C NMR and mass spectrometry analysis. All the synthesized compounds were evaluated for their biological activity. Compounds5a, 5b, 5c, 5d, 5e, 7g, 7h, 7j, 7l, 7n and7q were found to have better anti-inflammatory activity in the albumin denaturation technique. All compounds exhibited good antioxidant activity by DPPH radical scavenging assay and most compounds showed activity in a hydrogen peroxide assay. Molecular docking scores as well biological assays results suggested that compound7h has better anti-inflammatory activity among the synthesized compounds.