Association of a single nucleotide polymorphism in the akirin 2 gene with economically important traits in Korean native cattle. (30th May 2013)

• Record Type: Journal Article
• Authors: Kim, H.; Lee, S. K.; Hong, M. W.; Park, S. R.; Lee, Y. S.; Kim, J. W.; Lee, H. K.; Jeong, D. K.; Song, Y. H.; Lee, S. J.
• Is Part Of: Animal genetics. Volume 44:Number 6(2013:Dec.)
• Page Start: 750
• Page End: 753
• Publication Date: 2013-05-30
• Subjects: AKIRIN2 gene -- longissimus muscle area -- marbling score -- single nucleotide polymorphism; Animal genetics -- Periodicals; 572.8
• DOI: 10.1111/age.12055
• Languages: English
• ISSNs: 0268-9146

Abstract

Summary: The akirin 2 gene, located on chromosome 9 in cattle, was previously reported to be associated with nuclear factor‐kappa B (NF‐κB), involved in immune reactions and marbling of meat. To determine whether a single nucleotide polymorphism (SNP) in akirin 2 is associated with economically important traits of Korean native cattle, the c.*188G>A SNP DNA marker in the 3′‐UTR region of akirin 2 was analyzed for its association with carcass weight, longissimus muscle area and marbling. The c.*188G>A SNP was genotyped by polymerase chain reaction restriction fragment length polymorphism, and the frequency of the AA, AG, and GG genotypes were 6.82%, 71.29% and 21.88% respectively. This SNP was significantly associated with longissimus muscle area (Bonferroni corrected P < 0.05), and marbling score (Bonferroni corrected P < 0.01). These results suggest that the c.*188G>A SNP of akirin 2 might be useful as a DNA marker for longissimus muscle area and marbling scores in Korean native cattle.