Stereoselective synthesis of γ-hydroxy-α-amino acids through aldolase–transaminase recycling cascades. Issue 39 (3rd May 2017)

• Record Type: Journal Article
• Authors: Guérard-Hélaine, Christine; Heuson, Egon; Ndiaye, Moussa; Gourbeyre, Léa; Lemaire, Marielle; Hélaine, Virgil; Charmantray, Franck; Petit, Jean-Louis; Salanoubat, Marcel; de Berardinis, Véronique; Gefflaut, Thierry
• Is Part Of: Chemical communications. Volume 53:Issue 39(2017)
• Page Start: 5465
• Page End: 5468
• Publication Date: 2017-05-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc00742f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Efficient aldolase (AL)–transaminase (TA) recycling cascades were designed for the stereoselective synthesis of γ-hydroxy-α-amino acids with high atom economy. Abstract : Efficient bi-enzymatic cascades combining aldolases and α-transaminases were designed for the synthesis of γ-hydroxy-α-amino acids. These recycling cascades provide high stereoselectivity, atom economy, and an equilibrium shift of the transamination.l - syn or anti -4-hydroxyglutamic acid andd - anti -4, 5-dihydroxynorvaline were thus prepared in 83–95% yield in one step from simple substrates.