Impact of lipid composition and photosensitizer hydrophobicity on the efficiency of light-triggered liposomal release. Issue 18 (20th April 2017)

• Record Type: Journal Article
• Authors: Massiot, Julien; Makky, Ali; Di Meo, Florent; Chapron, David; Trouillas, Patrick; Rosilio, Véronique
• Is Part Of: Physical chemistry chemical physics. Volume 19:Issue 18(2017)
• Page Start: 11460
• Page End: 11473
• Publication Date: 2017-04-20
• Subjects: Chemistry, Physical and theoretical -- Periodicals; 541.3
• DOI: 10.1039/c7cp00983f
• Languages: English
• ISSNs: 1463-9076

Abstract

Abstract : Photo-triggerable liposomes are considered nowadays as promising drug delivery devices due to their potential to release encapsulated drugs in a spatial and temporal manner. Abstract : Photo-triggerable liposomes are considered nowadays as promising drug delivery devices due to their potential to release encapsulated drugs in a spatial and temporal manner. In this work, we have investigated the photopermeation efficiency of three photosensitizers (PSs), namely verteporfin, pheophorbide a and m -THPP when incorporated into liposomes with well-defined lipid compositions (SOPC, DOPC or SLPC). By changing the nature of phospholipids and PSs, the illumination of the studied systems was shown to significantly alter their lipid bilayer properties via the formation of lipid peroxides. The system efficiency depends on the PS/phospholipid association, and the ability of the PS to peroxidize acyl chains. Our results demonstrated the possible use of these three clinically approved (or under investigation) PSs as potential candidates for photo-triggerable liposome conception.