Synthesis of (E)-prop-1-ene-1, 3-diyldibenzene derivatives via direct decarboxylative coupling of α, β-unsaturated carboxylic acids with benzyl boronic acid pinacol ester. Issue 23 (7th June 2017)

• Record Type: Journal Article
• Authors: Zhu, Mingxiang; Qiu, Zhenjiang; Zhang, Yun; Du, Hongli; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
• Is Part Of: Tetrahedron letters. Volume 58:Issue 23(2017)
• Page Start: 2255
• Page End: 2257
• Publication Date: 2017-06-07
• Subjects: Decarboxylative cross-coupling -- Cinnamic acid derivatives -- Benzyl boronic acid pinacol ester; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.04.084
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A facile and efficient strategy for the construction of ( E )-prop-1-ene-1, 3-diyldibenzene derivatives has been developed. A broad range of ( E )-prop-1-ene-1, 3-diyldibenzene derivatives can be prepared from α, β-unsaturated carboxylic acids. The decarboxylative cross-coupling is easy-handled and wide applicability. Abstract: The first copper-catalyzed cross-coupling reaction between benzyl boronic acid pinacol ester and α, β-unsaturated carboxylic acids was described. The ready availability of the starting materials and excellent E selectivity make this protocol a safe and operationally convenient strategy for the efficient synthesis of ( E )-prop-1-ene-1, 3-diyldibenzene derivatives.