CuI mediated synthesis of heterocyclic flavone-benzofuran fused derivatives. Issue 23 (7th June 2017)

• Record Type: Journal Article
• Authors: Parveen, Iram; Ahmed, Naseem
• Is Part Of: Tetrahedron letters. Volume 58:Issue 23(2017)
• Page Start: 2302
• Page End: 2305
• Publication Date: 2017-06-07
• Subjects: Ullmann reaction -- Flavone-Benzofuran heterocycles -- CO bond formation -- Copper iodide; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.04.101
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Intramolecular Ullmann type synthesis. Highly efficient catalysts (CuI) in cross-coupling reactions. Tolerance of different functional groups. Effective for Cl groups. Low catalyst loading and short reaction time. Abstract: An efficient synthetic method of heterocyclic flavone benzofuran fused derivatives is reported in good to excellent yield (75–90%) via Ullmann type coupling reaction. The protocol involves catalytic amount of CuI (10 mol%) and K2 CO3 base for the intramolecular CO bond formation under mild reaction conditions.