FUT2 non‐secretor status is associated with Type 1 diabetes susceptibility in Japanese children. Issue 4 (15th December 2016)

• Record Type: Journal Article
• Authors: Ihara, K.; Fukano, C.; Ayabe, T.; Fukami, M.; Ogata, T.; Kawamura, T.; Urakami, T.; Kikuchi, N.; Yokota, I.; Takemoto, K.; Mukai, T.; Nishii, A.; Kikuchi, T.; Mori, T.; Shimura, N.; Sasaki, G.; Kizu, R.; Takubo, N.; Soneda, S.; Fujisawa, T.; Takaya, R.; Kizaki, Z.; Kanzaki, S.; Hanaki, K.; Matsuura, N.; Kasahara, Y.; Kosaka, K.; Takahashi, T.; Minamitani, K.; Matsuo, S.; Mochizuki, H.; Kobayashi, K.; Koike, A.; Horikawa, R.; Teno, S.; Tsubouchi, K.; Mochizuki, T.; Igarashi, Y.; Amemiya, S.; Sugihara, S.;
• Is Part Of: Diabetic medicine. Volume 34:Issue 4(2017)
• Page Start: 586
• Page End: 589
• Publication Date: 2016-12-15
• Subjects: Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.13288
• Languages: English
• ISSNs: 0742-3071

Abstract

Abstract: Aim: To examine the contribution of the FUT2 gene and ABO blood type to the development of Type 1 diabetes in Japanese children. Methods: We analysed FUT2 variants and ABO genotypes in a total of 531 Japanese children diagnosed with Type 1 diabetes and 448 control subjects. The possible association of FUT2 variants and ABO genotypes with the onset of Type 1 diabetes was statistically examined. Results: The se2 genotype (c.385A>T) of the FUT2 gene was found to confer susceptibility to Type 1A diabetes in a recessive effects model [odds ratio for se2/se2, 1.68 (95% CI 1.20–2.35); corrected P value = 0.0075]. Conclusions: The FUT2 gene contributed to the development of Type 1 diabetes in the present cohort of Japanese children. What's new?: This study suggests that the previously reported susceptibility gene, FUT2, contributes to the development of autoimmune Type 1 diabetes in Japanese children.