A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives under Pd(OAc)2/HCOOH system. Issue 23 (7th June 2017)

• Record Type: Journal Article
• Authors: Zhou, Yang; Chen, Ping; Lv, Xue; Niu, Junxing; Wang, Yingying; Lei, Min; Hu, Lihong
• Is Part Of: Tetrahedron letters. Volume 58:Issue 23(2017)
• Page Start: 2232
• Page End: 2235
• Publication Date: 2017-06-07
• Subjects: 2-Formylbenzoic acid -- Isoindolin-1-one -- Pd(OAc)2 -- Hydrogenation -- Cyclization; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.04.073
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: The isoindolin-1-ones are synthesized from 2-formylbenzoic acid and amine under Pd(OAc)2 /HCOOH system. This procedure is green, efficient, and high yields. This method is also suitable for the modification of natural products. Abstract: A facile and efficient method for the synthesis of N -substituted isoindolin-1-one derivatives from 2-formylbenzoic acid and amine under Pd(OAc)2 /HCOOH system has been described. The whole process is carried out in ligand-free conditions and furnished the desired products by reductive intramolecular cyclization. Furthermore, this procedure is applied successfully for the modification of natural products, such as vindoline and estrone.