Synthesis of poly(glycerol adipate)-g-oleate and its ternary phase diagram with glycerol monooleate and water. (June 2017)

• Record Type: Journal Article
• Authors: Bilal, Muhammad Humayun; Hussain, Hazrat; Prehm, Marko; Baumeister, Ute; Meister, Annette; Hause, Gerd; Busse, Karsten; Mäder, Karsten; Kressler, Jörg
• Is Part Of: European polymer journal. Volume 91(2017)
• Page Start: 162
• Page End: 175
• Publication Date: 2017-06
• Subjects: Glycerol monooleate -- Poly(glycerol adipate)-graft-oleate -- Cubic phases -- Nanoparticles; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; Polymerization; Polymers; Periodicals; Electronic journals; 547.705
• DOI: 10.1016/j.eurpolymj.2017.03.057
• Languages: English
• ISSNs: 0014-3057

Abstract

Graphical abstract: Highlights: Synthesis of Oleate grafted poly(glycerol adipate). Characterization, including nano domain formation. Effect on GMO-water mesophase structure in ternary phase diagram. Polymer/GMO hybrid nano particle formation. Abstract: Poly(glycerol adipate) (PGA) was synthesized by enzymatic polymerization and grafted with different amounts of oleoyl chloride. A series of graft copolymers PGA- g -Ox was obtained where O represents the oleate side chains and x is the degree of grafting (mol% of the pendant OH groups of PGA esterified) ranging from 11 to 90. Small angle X-ray scattering (SAXS) data revealed nanophase separation of the oleate side chains into nanodomains in bulk and wide angle X-ray scattering (WAXS) profiles showed a broad halo, reflecting the amorphous nature of the synthesized graft polymers. Glycerol monooleate (GMO), an amphiphilic lipid with one hydrophobic oleate tail and a glycerol hydrophilic head group, self-assembles into various liquid crystalline phases in the presence of water. Since oleate chains are integral part of both GMO and the graft copolymers, a certain degree of miscibility can be expected influencing the self-assembly behavior. Using SAXS for phase identification, systematic studies were carried out at room temperature on the ternary system of GMO/PGA- g -O22/water and the ternary phase diagram was constructed. The addition of polymer did influence the phase behavior of the GMO/water system. The water in the lamellar and cubic mesophases was partially replaced by PGA- g -O22. Furthermore, keeping the GMO/water ratio constant at 1:1, the addition of PGA- g -O22 lead to swelling of the water channels in the inverse bicontinuous Pn 3 m cubic phase. Preliminary investigations on the potential application of PGA- g -O22 as a stabilizer of structured nanoparticles in aqueous dispersions were carried out employing different transmission electron microscopy techniques.