Formulation, optimization, characterization and in-vitro drug release kinetics of atenolol loaded PLGA nanoparticles using 33 factorial design for oral delivery. (August 2016)

• Record Type: Journal Article
• Authors: Chourasiya, Vibha; Bohrey, Sarvesh; Pandey, Archna
• Is Part Of: Materials discovery. Volume 5(2016)
• Page Start: 1
• Page End: 13
• Publication Date: 2016-08
• Subjects: Atenolol -- Biodegradable polymer -- Factorial design -- In-vitro drug release -- Kinetic models -- Nanoprecipitation method; Materials -- Periodicals; Materials; Electronic journals; Periodicals; 677.4
• DOI: 10.1016/j.md.2016.12.002
• Languages: English
• ISSNs: 2352-9245

Abstract

Graphical abstract: Abstract: This work was aimed to formulate the atenolol loaded PLGA nanoparticles through optimizing formulation variables using 3 3 factorial design. FTIR studies were performed to examine the interaction between the excipients used. These nanoparticles were characterized by size, shape, zeta potential, % drug entrapment efficiency, process yield and in-vitro drug release behavior. Different kinetics models were used to analyze the in-vitro drug release data. Preferred formulation showed particle size 192.6 ± 3.5 nm, PDI 0.234 ± 0.008, −32.4 mV zeta potential, drug entrapment efficiency 71.65 ± 1.8% and 78.32 ± 1.1% process yield. TEM results showed that these nanoparticles were spherical in shape and follow the Korsmeyer-Peppas model.