How does sex matter? Behavior, stress and animal models of neurobehavioral disorders. (May 2017)
- Record Type:
- Journal Article
- Title:
- How does sex matter? Behavior, stress and animal models of neurobehavioral disorders. (May 2017)
- Main Title:
- How does sex matter? Behavior, stress and animal models of neurobehavioral disorders
- Authors:
- Palanza, Paola
Parmigiani, Stefano - Abstract:
- Highlights: Several neurobehavioral disorders exhibit sex differences in vulnerability, incidence and treatment response. Most translational neuroscience experiments use only male mice or rats. Mice show sexually differentiated responses to environmental, social and developmental factors. A sex-specific vulnerability to stress and related neurobehavioral disorders exists. Data obtained in males may be irrelevant for inferring psychopathology and treatments for females. Abstract: Many aspects of brain functioning exhibit important sex differences that affect behavior, mental health and mental disorders. However, most translational neuroscience research related to animal models of neurobehavioral disorders are carried out in male animals only. Based on published data from our laboratory on the House mouse, we discuss the following issues: (1) sex differences in social behavior of wild-derived mice; (2) artificial selection of laboratory strains and its consequences on social and reproductive competition; (3) sex-dependent effects of common experimental procedures; (4) differential effects of developmental events: the case of endocrine disruption; (5) implications for female models of stress and neurobehavioral disorders. Altogether, this review of data outline the marked differences of male and female responses to different social challenges and evinces the current lack of a relevant female mouse model of social stress. Whilst animal modelling is an important approach towardsHighlights: Several neurobehavioral disorders exhibit sex differences in vulnerability, incidence and treatment response. Most translational neuroscience experiments use only male mice or rats. Mice show sexually differentiated responses to environmental, social and developmental factors. A sex-specific vulnerability to stress and related neurobehavioral disorders exists. Data obtained in males may be irrelevant for inferring psychopathology and treatments for females. Abstract: Many aspects of brain functioning exhibit important sex differences that affect behavior, mental health and mental disorders. However, most translational neuroscience research related to animal models of neurobehavioral disorders are carried out in male animals only. Based on published data from our laboratory on the House mouse, we discuss the following issues: (1) sex differences in social behavior of wild-derived mice; (2) artificial selection of laboratory strains and its consequences on social and reproductive competition; (3) sex-dependent effects of common experimental procedures; (4) differential effects of developmental events: the case of endocrine disruption; (5) implications for female models of stress and neurobehavioral disorders. Altogether, this review of data outline the marked differences of male and female responses to different social challenges and evinces the current lack of a relevant female mouse model of social stress. Whilst animal modelling is an important approach towards understanding mechanisms of neurobehavioral disorders, it is evident that data obtained in males may be irrelevant for inferring psychopathology and efficacy of pharmacological treatments for females. … (more)
- Is Part Of:
- Neuroscience and biobehavioral reviews. Volume 76:Part A(2017)
- Journal:
- Neuroscience and biobehavioral reviews
- Issue:
- Volume 76:Part A(2017)
- Issue Display:
- Volume 76, Issue 1 (2017)
- Year:
- 2017
- Volume:
- 76
- Issue:
- 1
- Issue Sort Value:
- 2017-0076-0001-0000
- Page Start:
- 134
- Page End:
- 143
- Publication Date:
- 2017-05
- Subjects:
- House mouse -- Sex differences -- Aggression -- Social stress -- Female models -- Development
Psychophysiology -- Periodicals
Human behavior -- Periodicals
Animal behavior -- Periodicals
Neurology -- Periodicals
Behavior -- Periodicals
Ethology -- Periodicals
Neurology -- Periodicals
Psychophysiologie -- Périodiques
Comportement humain -- Périodiques
Animaux -- Mœurs et comportement -- Périodiques
Neurologie -- Périodiques
Animal behavior
Human behavior
Neurology
Psychophysiology
Periodicals
Electronic journals
573.8 - Journal URLs:
- http://www.sciencedirect.com/science/journal/01497634 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.neubiorev.2017.01.037 ↗
- Languages:
- English
- ISSNs:
- 0149-7634
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6081.561000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 2670.xml