Modulation of host immune responses to Toxoplasma gondii by microRNAs. (February 2017)

• Record Type: Journal Article
• Authors: Cai, Y.; Shen, J.
• Other Names: Britton Collette guestEditor.
• Is Part Of: Parasite immunology. Volume 39:Number 2(2017:Feb.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-02
• Subjects: disease -- gene expression -- immune modulation -- immunological terms -- parasite -- tools and techniques -- Toxoplasma gondii -- toxoplasmosis; Veterinary parasitology -- Immunological aspects -- Periodicals; Host-parasite relationships -- Immunological aspects -- Periodicals; 571.96
• DOI: 10.1111/pim.12417
• Languages: English
• ISSNs: 0141-9838

Abstract

Summary: To survive successfully, Toxoplasma counteracts the strictly regulated host innate response to downregulate inflammation that could be deleterious for the parasite. MicroRNAs are vital regulators of both innate and adaptive immunity, controlling the maintenance and development of immune progenitors as well as the differentiation and the functions of host mature immune cells. Thus, the complexity of mechanisms underlying the connection between Toxoplasma and host immunity has led to investigations of miRNAs as additional key molecular players. The knowledge acquired from these studies will be useful for aiding the discovery of new targets for diagnosis or therapeutic approaches for toxoplasmosis and insight into the interaction between host and parasite.