Periictal activity in cooled asphyxiated neonates with seizures. (April 2017)

• Record Type: Journal Article
• Authors: Major, Philippe; Lortie, Anne; Dehaes, Mathieu; Lodygensky, Gregory Anton; Gallagher, Anne; Carmant, Lionel; Birca, Ala
• Is Part Of: Seizure. Volume 47(2017)
• Page Start: 13
• Page End: 16
• Publication Date: 2017-04
• Subjects: HIE hypoxic-ischemic encephalopathy -- TH therapeutic hypothermia -- GA gestational age -- HFO high-frequency oscillations; Critically ill neonates -- Seizure reoccurrence -- Seizure prediction -- Hypoxic-ischemic encephalopathy -- Spectral power -- Therapeutic hypothermia; Epilepsy -- Periodicals; Epilepsy -- Periodicals; Seizures -- Periodicals; Épilepsie -- Périodiques; Electronic journals; Electronic journals; 616.853
• DOI: 10.1016/j.seizure.2017.03.002
• Languages: English
• ISSNs: 1059-1311

Abstract

Highlights: Seizures are common and worsen the outcome in critically ill neonates. Predicting seizure reoccurrence could enable individual treatment and better outcome. Distinct alpha activity preceded seizures that reoccurred on rewarming. Preictal alpha activity may indicate propensity for seizure reoccurrence. Abstract: Purpose: Seizures are common in critically ill neonates. Both seizures and antiepileptic treatments may lead to short term complications and worsen the outcomes. Predicting the risks of seizure reoccurrence could enable individual treatment regimens and better outcomes. We aimed to identify EEG signatures of seizure reoccurrence by investigating periictal electrographic features and spectral power characteristics in hypothermic neonates with hypoxic-ischemic encephalopathy (HIE) with or without reoccurrence of seizures on rewarming. Methods: We recruited five consecutive HIE neonates, submitted to continuous EEG monitoring, with high seizure burden (>20% per hour) while undergoing therapeutic hypothermia. Two of them had reoccurrence of seizures on rewarming. We performed quantitative analysis of fifteen artifact-free consecutive seizures to appreciate spectral power changes between the interictal, preictal and ictal periods, separately for each patient. Visual analysis allowed description of electrographic features associated with ictal events. Results: Every patient demonstrated a significant increase in overall spectral power from the interictal to preictal and ictal periods (p < 0.01). Alpha power increase was more pronounced in the two patients with reoccurrence of seizures on rewarming and significant when comparing both interictal-to-preictal and interictal-to-ictal periods. This alpha activity increase could be also appreciated using visual analysis and distinguished neonates with and without seizure reoccurrence. Conclusion: This distinct alpha activity preceding ictal onset could represent a biomarker of propensity for seizure reoccurrence in neonates. Future studies should be performed to confirm whether quantitative periictal characteristics and electrographic features allow predicting the risks of seizure reoccurrence in HIE neonates and other critically ill patients.