Vitamin D receptor gene polymorphisms association with the risk of sepsis and mortality. (12th April 2017)

• Record Type: Journal Article
• Authors: Zeljic, K.; Elkilany, A.; Supic, G.; Surbatovic, M.; Djordjevic, D.; Magic, Z.; Bozic, B.
• Is Part Of: International journal of immunogenetics. Volume 44:Number 3(2017:Jun.)
• Page Start: 129
• Page End: 134
• Publication Date: 2017-04-12
• Subjects: mortality -- polymorphisms -- risk -- sepsis -- VDR; Immunogenetics -- Periodicals; 571.9648
• DOI: 10.1111/iji.12318
• Languages: English
• ISSNs: 1744-3121

Abstract

Summary: Association of vitamin D receptor (VDR) gene polymorphisms with sepsis risk and mortality was studied. VDR FokI CC genotype was associated with increased sepsis risk (OR = 13.396, p = .000009) compared to the TT genotype. Results suggest possible role of VDR FokI (rs2228570) as a molecular biomarker of increased sepsis risk.