Severe excessive daytime sleepiness induced by hydroxyurea. (24th January 2017)

• Record Type: Journal Article
• Authors: Revol, Bruno; Joyeux‐Faure, Marie; Albahary, Marie‐Victoire; Gressin, Remy; Mallaret, Michel; Pepin, Jean‐Louis; Launois, Sandrine H.
• Is Part Of: Fundamental & clinical pharmacology. Volume 31:Number 3(2017:Jun.)
• Page Start: 367
• Page End: 368
• Publication Date: 2017-01-24
• Subjects: excessive daytime sleepiness -- hydroxyurea -- unexpected adverse drug reaction; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/fcp.12260
• Languages: English
• ISSNs: 0767-3981

Abstract

Abstract: Excessive daytime sleepiness (EDS) has been reported with many drugs, either as an extension of a hypnotic effect (e.g. central nervous system depressants) or as an idiosyncratic response of the patient. Here, we report unexpected and severe subjective and objective EDS induced by hydroxyurea therapy, with a favorable outcome after withdrawal. Clinical history, sleep log, polysomnography, and multiple sleep latency tests confirming the absence of other EDS causes are presented.