Predictive factors of overall quality of life in advanced cancer patients using EORTC QLQ-C30. (February 2014)

• Record Type: Journal Article
• Authors: Cramarossa, Gemma; Zeng, Liang; Zhang, Liying; Tseng, Ling-Ming; Hou, Ming-Feng; Fairchild, Alysa; Vassiliou, Vassilios; Jesus-Garcia, Reynaldo; Alm El-Din, Mohamed A; Kumar, Aswin; Forges, Fabien; Chie, Wei-Chu; Sahgal, Arjun; Lam, Henry; Pulenzas, Natalie; Chow, Edward
• Is Part Of: Expert review of pharmacoeconomics & outcomes research. Volume 14:Number 1(2014)
• Page Start: 139
• Page End: 146
• Publication Date: 2014-02
• Subjects: advanced cancer -- EORTC QLQ-C30 -- metastatic cancer -- quality of life -- symptom control; Pharmacology -- Economic aspects -- Periodicals; 338.47615105
• DOI: 10.1586/14737167.2014.864560
• Languages: English
• ISSNs: 1473-7167

Abstract

Abstract : Objective: To identify which domains/symptoms from the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) were predictive of overall quality of life (QoL) in advanced cancer patients. Methods: Four hundred and forty seven patients with brain metastases or bone metastases from seven countries were enrolled with regression analysis to determine the predictive value of the QLQ-C30 functional/symptom scores for patient reported overall QoL (question 30), overall health (question 29) and the global health status domain (questions 29 and 30). Results: Worse role functioning, social functioning, fatigue and financial problems were the most significant predictive factors for worse QoL. In the bone metastases subgroup (n = 400), role functioning, fatigue and financial problems were the most significant predictors. In patients with brain metastases (n = 47), none of the EORTC domains significantly predicted worse QOL. Conclusion: Deterioration of certain QLQ-C30 functional/symptom scores significantly contributes to worse QoL, overall health and global health status.