Regioselective Synthesis of the FXR Antagonist E‐Guggulsterone from Three Natural Steroids. (7th April 2017)
- Record Type:
- Journal Article
- Title:
- Regioselective Synthesis of the FXR Antagonist E‐Guggulsterone from Three Natural Steroids. (7th April 2017)
- Main Title:
- Regioselective Synthesis of the FXR Antagonist E‐Guggulsterone from Three Natural Steroids
- Authors:
- Chin, Jungwook
Hahn, Dongyup
Won, Dong Hwan
Cho, Sung Jin
Kim, Kyung‐Hee
Ham, Jungyeob
Kang, Heonjoong - Abstract:
- Abstract : In our attempt to develop a method to synthesize E ‐ and Z ‐guggulsterones [antagonists of farnesoid X receptor (FXR)], we have succeeded in synthesizing E ‐guggulsterone selectively from three steroids, viz, 4‐androsten‐3, 17‐dione (2 ), 5‐androsten‐3β‐ol‐17‐one (DHEA) (3 ), and testosterone (4 ), in 68, 86 and 62% overall yield, respectively. We also investigated the biological effects of the synthetic E ‐ and Z ‐guggulsterones and found that E ‐guggulsterone was more potent than Z ‐guggulsterone in inhibiting FXR transactivation Abstract :
- Is Part Of:
- Bulletin of the Korean Chemical Society. Volume 38:Number 5(2017)
- Journal:
- Bulletin of the Korean Chemical Society
- Issue:
- Volume 38:Number 5(2017)
- Issue Display:
- Volume 38, Issue 5 (2017)
- Year:
- 2017
- Volume:
- 38
- Issue:
- 5
- Issue Sort Value:
- 2017-0038-0005-0000
- Page Start:
- 525
- Page End:
- 529
- Publication Date:
- 2017-04-07
- Subjects:
- Guggulsterone -- Natural steroid -- Farnesoid X receptor antagonist -- Lipid disorders -- Regioselective synthesis
Chemistry -- Periodicals
540.5 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1229-5949 ↗
- DOI:
- 10.1002/bkcs.11120 ↗
- Languages:
- English
- ISSNs:
- 0253-2964
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD Digital store
- Ingest File:
- 1286.xml