Neuron–Material Nanointerfaces: Surface Nanotopography Governs Neuronal Differentiation and Development. Issue 5 (26th April 2017)

• Record Type: Journal Article
• Authors: Kim, Hoon Kee; Kim, Eunha; Jang, Hongje; Kim, Young‐Kwan; Kang, Kyungtae
• Is Part Of: ChemNanoMat. Volume 3:Issue 5(2017)
• Page Start: 278
• Page End: 287
• Publication Date: 2017-04-26
• Subjects: cell adhesion -- nanostructures -- neurite development -- neurochemistry -- stem cell differentiation; Nanochemistry -- Periodicals; Nanostructured materials -- Periodicals; Nanochemistry; Nanostructured materials; Periodicals; 541.2
• DOI: 10.1002/cnma.201700063
• Languages: English
• ISSNs: 2199-692X

Abstract

Abstract: This review summarizes recent experimental results regarding the influences of surface nanotopography on stem cell differentiation into neurons and neuronal development. Collections of observations and their interpretations are provided. We specifically focus on the in vivo implications of the results, by suggesting that: (i) neural cells use their intracellular machineries to actively recognize surface nanotopography; (ii) the preferential differentiation of stem cells into neurons and the developmental acceleration of neurons occur on a range of similar nanotopographical features, implying that they have similar biological backgrounds; and (iii) surface nanotopography, therefore, is deeply involved in brain development. We believe that this review will provide biological insights to the field of nano–neuron interfaces and encourage interdisciplinary efforts capable of addressing unsolved biological problems and increasing engineering needs. Abstract : Neuro–Nano : This review summarizes recent experimental results regarding influences of surface nanotopography on stem cell differentiation into neurons and neuronal development. Collections of observations and their interpretations are provided with the aim to provide biological insights to the field of nano–neuron interfaces and encourage interdisciplinary efforts.