Fingerprinting antibiotics with PAE-based fluorescent sensor arrays. Issue 17 (12th April 2017)

• Record Type: Journal Article
• Authors: Han, Jinsong; Wang, Benhua; Bender, Markus; Pfisterer, Jessica; Huang, Wei; Seehafer, Kai; Yazdani, Mahdieh; Rotello, Vincent M.; Rotello, Caren M.; Bunz, Uwe H. F.
• Is Part Of: Polymer chemistry. Volume 8:Issue 17(2017)
• Page Start: 2723
• Page End: 2732
• Publication Date: 2017-04-12
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/c7py00227k
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : We outline an evolution process for 30 tongue elements composed of poly( p -aryleneethynylene)s (PAE) and surfactants, resulting in a powerful pruned tongue for the discrimination of antibiotics. Abstract : We outline an evolution process for tongue elements composed of poly( p -aryleneethynylene)s (PAE) and detergents, resulting in a chemical tongue (24 elements) that discerns antibiotics. Cross-breeding of this new tongue with tongue elements that consist of simple poly( p -phenyleneethynylene)s (PPE) at different pH-values leads to an enlarged sensor array, composed of 30 elements. This tongue was pruned, employing principal component analysis. We found that a filial tongue featuring three elements from each original array ( i.e. a six element tongue) is superior to either of the prior tongues and the composite tongue in the discrimination of structurally different antibiotics. Such a selection process should be general and give an idea how to successfully generate powerful low-selectivity sensor elements and configure them into discriminative chemical tongues.