Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal in vivo imaging. Issue 3 (30th March 2017)

• Record Type: Journal Article
• Authors: Kim, Sungwan; Yun, Gyeongwon; Khan, Suman; Kim, Jinhwan; Murray, James; Lee, Yeong Mi; Kim, Won Jong; Lee, Gyudong; Kim, Sungjee; Shetty, Dinesh; Kang, Joo Hyun; Kim, Jung Young; Park, Kyeng Min; Kim, Kimoon
• Is Part Of: Materials horizons. Volume 4:Issue 3(2017:May)
• Page Start: 450
• Page End: 455
• Publication Date: 2017-03-30
• Subjects: Materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c7mh00038c
• Languages: English
• ISSNs: 2051-6347

Abstract

Abstract : A new polymer nanocapsule was used as a versatile platform for multimodal in vivo imaging. Abstract : Cucurbit[6]uril (CB[6])-based polymer nanocapsules (CB[6]PNs) were used as a multimodal platform for cancer-targeted in vivo bioimaging. By taking advantage of the strong and robust host–guest interaction between CB[6] and spermidine (spmd) under in vivo conditions, the surface of the CB[6]PNs was non-covalently modified with various spmd-conjugated functionalities in a modular manner. The CB[6]PNs modified with imaging probes and targeting ligands showed tumor targeted PET and NIR imaging in mice. This proof of concept demonstrates the potential of non-covalently modified nanomaterials in real world in vivo systems.