Layered double hydroxide bio-composites toward excellent systematic anticancer therapy. Issue 17 (13th April 2017)

• Record Type: Journal Article
• Authors: Mei, Xuan; Liang, Ruizheng; Peng, Liuqi; Hu, Tongyang; Wei, Min
• Is Part Of: Journal of materials chemistry. Volume 5:Issue 17(2017)
• Page Start: 3212
• Page End: 3216
• Publication Date: 2017-04-13
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c7tb00209b
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A supramolecular bio-composite with an excellent chemotherapy–PDT synergistic anticancer effect is fabricated and shows potential application in the field of cancer therapy. Abstract : Multi-therapeutic methodologies have attracted considerable attention toward cancer therapy, which can overcome the limitation of a single therapy and achieve an optimized anticancer efficacy. Herein, we prepared a systematic anticancer drug by intercalating zinc phthalocyanines (ZnPc) into a layered double hydroxide (LDH) gallery, followed by loading doxorubicin (DOX) on the surface (denoted as ZnPc-DOX/LDH). ZnPc is accommodated in the interlayer region of the LDH, which results in a largely enhanced photodynamic therapeutic (PDT) efficiency; while the physisorbed DOX affords a chemotherapeutic effect. In vitro tests performed with KB cells indicate a synergistic anticancer performance as well as excellent biocompatibility compared with pristine ZnPc and DOX. This study demonstrates a promising bio-composite for PDT–chemotherapy systematic therapy, which shows potential application in the field of cancer therapy.