Grandiflodines A and B, two novel diterpenoid alkaloids from Delphinium grandiflorum. Issue 39 (3rd May 2017)

• Record Type: Journal Article
• Authors: Chen, Neng-Hua; Zhang, Yu-Bo; Li, Wen; Li, Pan; Chen, Li-Feng; Li, Yao-Lan; Li, Guo-Qiang; Wang, Guo-Cai
• Is Part Of: RSC advances. Volume 7:Issue 39(2017)
• Page Start: 24129
• Page End: 24132
• Publication Date: 2017-05-03
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra02869e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Two novel diterpenoid alkaloids, grandiflodines A and B (1 and2 ), were isolated from Delphinium grandiflorum . Abstract : Two novel diterpenoid alkaloids, grandiflodines A and B (1 and2 ), were isolated from Delphinium grandiflorum . Compound1 represents a rare hetisine-type C20 -diterpenoid alkaloid in which the bond between the atoms of N and C-17 is broken. Compound2 features an unusual lycoctonine-type C19 -diterpenoid alkaloid skeleton with the cleavage of N–C19 and C7 –C17 bonds, and the construction of the N–C7 bond. Structural elucidations of the isolates were performed by spectroscopic analysis, X-ray diffraction and comparison with the literature. These compounds were tested for their antiviral and anti-inflammatory activities.