New diterpene alkaloids from the marine sponge Agelas mauritiana. Issue 39 (3rd May 2017)

• Record Type: Journal Article
• Authors: Hong, Li-Li; Sun, Jia-Bao; Yang, Fan; Liu, Man; Tang, Jie; Sun, Fan; Jiao, Wei-Hua; Wang, Shu-Ping; Zhang, Wei; Lin, Hou-Wen
• Is Part Of: RSC advances. Volume 7:Issue 39(2017)
• Page Start: 23970
• Page End: 23976
• Publication Date: 2017-05-03
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra02547e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Chemical investigation of the sponge Agelas mauritiana led to the isolation of five new diterpene alkaloids and two known compounds, in which (+)-agelasine B (2 ) and agelasine D (7 ) showed potent antibacterial activity. Abstract : Chemical investigation of an ethanol extract of the sponge Agelas mauritiana led to the isolation and characterization of five new diterpene alkaloids, namely, (−)-8′-oxo-agelasine B (1 ), (+)-agelasine B (2 ), (+)-8′-oxo-agelasine C (3 ), agelasine V (4 ), and (+)-8′-oxo-agelasine E (5 ), along with two known compounds, (−)-8′-oxo-agelasine D (6 ), and agelasine D (7 ). The structures of these compounds were determined by interpretation of spectroscopic data and comparison with literature properties. Compounds1 and3–5 are the second example of 8′-oxo-agelasine analogs. Compounds2 and7 not only exhibited moderate cytotoxicity toward the cancer cell lines PC9, A549, HepG2, MCF-7, and U937 with IC50 values of 4.49–14.41 μM, but also showed potent antibacterial activities against a panel of methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates with MIC90 values of 1–8 μg mL −1 .