Validated Risk Score for Predicting 6‐Month Mortality in Infective Endocarditis. Issue 4 (April 2016)

• Record Type: Journal Article
• Authors: Park, Lawrence P.; Chu, Vivian H.; Peterson, Gail; Skoutelis, Athanasios; Lejko‐Zupa, Tatjana; Bouza, Emilio; Tattevin, Pierre; Habib, Gilbert; Tan, Ren; Gonzalez, Javier; Altclas, Javier; Edathodu, Jameela; Fortes, Claudio Querido; Siciliano, Rinaldo Focaccia; Pachirat, Orathai; Kanj, Souha; Wang, Andrew
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Ralph investigator.; Durack David T. investigator.; Eykyn Susannah investigator.; Fowler Vance G. investigator.; Hoen Bruno investigator.; Miró José M. investigator.; Moreillon Phillipe investigator.; Olaison Lars investigator.; Raoult Didier investigator.; Rubinstein Ethan investigator.; Sexton Daniel J. investigator.;
• Is Part Of: Journal of the American Heart Association. Volume 5:Issue 4(2016)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-04
• Subjects: infection -- mortality -- prognosis -- surgery -- valves; Heart -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; Cerebrovascular disease -- Periodicals; Cardiology -- Periodicals; 616.1
• DOI: 10.1161/JAHA.115.003016
• Languages: English
• ISSNs: 2047-9980

Abstract

Abstract : Background: Host factors and complications have been associated with higher mortality in infective endocarditis (IE). We sought to develop and validate a model of clinical characteristics to predict 6‐month mortality in IE. Methods and Results: Using a large multinational prospective registry of definite IE (International Collaboration on Endocarditis [ICE]–Prospective Cohort Study [PCS], 2000–2006, n=4049), a model to predict 6‐month survival was developed by Cox proportional hazards modeling with inverse probability weighting for surgery treatment and was internally validated by the bootstrapping method. This model was externally validated in an independent prospective registry (ICE‐PLUS, 2008–2012, n=1197). The 6‐month mortality was 971 of 4049 (24.0%) in the ICE‐PCS cohort and 342 of 1197 (28.6%) in the ICE‐PLUS cohort. Surgery during the index hospitalization was performed in 48.1% and 54.0% of the cohorts, respectively. In the derivation model, variables related to host factors (age, dialysis), IE characteristics (prosthetic or nosocomial IE, causative organism, left‐sided valve vegetation), and IE complications (severe heart failure, stroke, paravalvular complication, and persistent bacteremia) were independently associated with 6‐month mortality, and surgery was associated with a lower risk of mortality (Harrell's C statistic 0.715). In the validation model, these variables had similar hazard ratios (Harrell's C statistic 0.682), with a similar, independent benefit of surgery (hazard ratio 0.74, 95% CI 0.62–0.89). A simplified risk model was developed by weight adjustment of these variables. Conclusions: Six‐month mortality after IE is ≈25% and is predicted by host factors, IE characteristics, and IE complications. Surgery during the index hospitalization is associated with lower mortality but is performed less frequently in the highest risk patients. A simplified risk model may be used to identify specific risk subgroups in IE.