Cell-borne 2D nanomaterials for efficient cancer targeting and photothermal therapy. (July 2017)

• Record Type: Journal Article
• Authors: Li, Zhibin; Shao, Jundong; Luo, Qian; Yu, Xue-Feng; Xie, Hanhan; Fu, Haidi; Tang, Siying; Wang, Huaiyu; Han, Guangli; Chu, Paul K.
• Is Part Of: Biomaterials. Volume 133(2017)
• Page Start: 37
• Page End: 48
• Publication Date: 2017-07
• Subjects: 2D nanomaterials -- Bi2Se3 nanosheets -- Near-infrared -- Drug delivery -- Photothermal therapy; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2017.04.012
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Two of the challenges for clinical implementation of nano-therapeutic strategies are optimization of tumor targeting and clearance of the nanoagents in vivo . Herein, a cell-mediated therapy by transporting 2D Bi2 Se3 nanosheets within macrophage vehicles is described. The Bi2 Se3 nanosheets with excellent near-infrared photothermal performance exhibit high macrophage uptake and negligible cytotoxicity thus facilitating the fabrication of Bi2 Se3 -laden-macrophages. Compared with bare Bi2 Se3, the Bi2 Se3 -laden-macrophages after intravenous injection show prolonged blood circulation and can overcome the hypoxia-associated drug delivery barrier to target the tumor efficiently and dramatically enhance the efficiency of photothermal cancer therapy. The Bi2 Se3 -laden-macrophages possess good biocompatibility as demonstrated by the biochemical and histological analyses and furthermore, most of the materials are excreted from the body within 25 days. Our findings reveal a desirable system for highly efficient near-infrared photothermal cancer therapy.