Potential Nutrients for Preventing or Treating Bronchopulmonary Dysplasia. (March 2017)

• Record Type: Journal Article
• Authors: Ma, Liya; Zhou, Ping; Neu, Josef; Lin, Hung-Chih
• Is Part Of: Paediatric respiratory reviews. Volume 22(2017)
• Page Start: 83
• Page End: 88
• Publication Date: 2017-03
• Subjects: BPD Bronchopulmonary dysplasia -- RDS respiratory distress syndrome -- VLBW very low birth weight -- ELBW extremely low birth weight -- NAC N-acetylcysteine -- RCT randomized controlled trial -- PN parenteral nutrition -- GSH glutathione -- NO nitric oxide -- GPx glutathione peroxidase -- LCPUFAs Long chain polyunsaturated fatty acids -- DHA docosahexaenoic acid -- ROP retinopathy of prematurity; Bronchopulmonary dysplasia -- nutrient -- vitamin A -- long chain polyunsaturated fatty acids -- L-citrulline; Pediatric respiratory diseases -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory Therapy -- Periodicals; Child -- Periodicals; Appareil respiratoire -- Infections, chez l'enfant -- Périodiques; Appareil respiratoire -- Maladies, chez l'enfant -- Périodiques; 618.922
• DOI: 10.1016/j.prrv.2016.08.013
• Languages: English
• ISSNs: 1526-0542

Abstract

Summary: Bronchopulmonary dysplasia (BPD) is a frequent complication occurring in extremely preterm infants. Despite recent advances in newborn medicine, the incidence of BPD does not appear to have changed markedly, and specific treatments and prevention strategies are still lacking. Nutrition plays an important role in normal lung development and maturation. Malnutrition may delay somatic growth and new alveoli development, thus aggravating pulmonary injury involved in the pathogenesis of BPD. However, few nutrients have been investigated for their potential to mitigate the pathogenesis of BPD. In this article, we reviewed the recent progress in research on potential nutrients useful for the prevention or treatment of BPD, including glutamine, cysteine and N-acetylcysteine, L-arginine and L-citrulline, long chain polyunsaturated fatty acids (LCPUFAs), inositol, selenium, and some antioxidant vitamins including vitamin A. Current evidence shows that vitamin A and LCPUFA can prevent BPD, and that L-citrulline might provide a new method to treat chronic pulmonary hypertension associated with BPD in premature infants. The effects of other nutrients on BPD prevention need to be further studied.