Gastric-type H+, K+-ATPase in mouse vestibular end organs. (4th May 2017)

• Record Type: Journal Article
• Authors: Takumida, Masaya; Takumida, Hiroshi; Anniko, Matti
• Is Part Of: Acta oto-laryngologica. Volume 137:Number 5(2017)
• Page Start: 455
• Page End: 459
• Publication Date: 2017-05-04
• Subjects: Hydrogen, potassium-adenosine triphosphatase -- vestibular end organ -- immunohistochemistry; Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.1080/00016489.2016.1245865
• Languages: English
• ISSNs: 0001-6489

Abstract

Abstract: Conclusion: Gastric type H +, K + -ATPase in the vestibular end organs may be of importance for K + circulation and may also be related to pH regulation in vestibular end organs and endolymphatic sac. Objective: To analyze the expression of gastric-type H +, K + -ATPase in normal mouse vestibular end organs. Methods: 8 weeks old CBA/J mice were used in this study. The presence of gastric-type H +, K + -ATPase α and β in the vestibular end organs, viz. utricle, saccule, ampulla, vestibular ganglion, and endolymphatic sac, was investigated using immunohistochemistry. Results: In the vestibular end organs, H +, K + -ATPase α and β were almost identical. H +, K + -ATPase was expressed in sensory cells, the basolateral surface of dark cells, fibrocytes, in vestibular ganglion cells, and in the upper region of the endolymphatic sac epithelial cells.