Propeptide big-endothelin, N-terminal-pro brain natriuretic peptide and mortality. The Ludwigshafen risk and cardiovascular health (LURIC) study. (19th May 2017)

• Record Type: Journal Article
• Authors: Gergei, Ingrid; Krämer, Bernhard K.; Scharnagl, Hubert; Stojakovic, Tatjana; März, Winfried; Mondorf, Ulrich
• Is Part Of: Biomarkers. Volume 22:Number 3/4(2017)
• Page Start: 315
• Page End: 320
• Publication Date: 2017-05-19
• Subjects: N-terminal-pro brain natriuretic peptide -- big endothelin-1 -- congestive heart failure -- cardiovascular mortality -- biomarker; Biochemical markers -- Periodicals; 610.28
• DOI: 10.1080/1354750X.2016.1252969
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Context: The endothelin system (Big-ET-1) is a key regulator in cardiovascular (CV) disease and congestive heart failure (CHF). Objectives: We have examined the incremental value of Big-ET-1 in predicting total and CV mortality next to the well-established CV risk marker N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP). Methods: Big-ET-1 and NT-proBNP were determined in 2829 participants referred for coronary angiography (follow-up 9.9 years). Results: Big-ET-1 is an independent predictor of total, CV mortality and death due to CHF. Discussion: The conjunct use of Big-ET-1 and NT-proBNP improves the risk stratification of patients with intermediate to high risk of CV death and CHF. Conclusions: Big-ET-1improves risk stratification in patients referred for coronary angiography.