Ruthenium(II)–Arene Metallacycles: Crystal Structures, Interaction with DNA, and Cytotoxicity. Issue 12 (16th February 2017)

• Record Type: Journal Article
• Authors: Wang, Hong‐Yan; Qian, Yong; Wang, Fang‐Xin; Habtemariam, Abraha; Mao, Zong‐Wan; Sadler, Peter J.; Liu, Hong‐Ke
• Other Names: Alessio Enzo guestEditor.; Guo Zijian guestEditor.
• Is Part Of: European journal of inorganic chemistry. Issue 12(2017)
• Page Start: 1792
• Page End: 1799
• Publication Date: 2017-02-16
• Subjects: Metallacycles -- Coordination complexes -- Ruthenium -- Macrocycles -- DNA -- Cancer; Chemistry, Inorganic -- Periodicals; Organometallic chemistry -- Periodicals; Bioinorganic chemistry -- Periodicals; Solid state chemistry -- Periodicals; 546
• DOI: 10.1002/ejic.201601226
• Languages: English
• ISSNs: 1434-1948

Abstract

Abstract : A series of 24, 26‐membered Ru II 2 metallamacrocycles containing 1‐{3‐[(1 H ‐imidazol‐1‐yl)methyl]benzyl}‐1 H ‐imidazole ( m ‐bib) and 1‐{4‐[(1 H ‐imidazol‐1‐yl)methyl]benzyl}‐1 H ‐imidazole ( p ‐bib) ligands have been synthesized and characterized. X‐ray crystal structures of [Ru2 (η 6 ‐p ‐cymene)2 ( m ‐bib)2 Cl2 ](CF3 SO3 )2 (2 ), [Ru2 (η 6 ‐p ‐cymene)2 ( m ‐bib)2 Cl2 ](SbF6 )2 (3 ), [Ru2 (η 6 ‐p ‐cymene)2 ( m ‐bib)2 I2 ]I2 (6 ), and [Ru2 (η 6 ‐p ‐cymene)2 ( p ‐bib)2 Cl2 ](CF3 SO3 )2 (8 ) were determined and found to exhibit chair‐like conformations. In general, the complexes exhibited little or moderate anti‐proliferative activity towards cancer cells [human lung cancer cells (A549), breast adenocarcinoma cells (MCF‐7), cervical epithelioid carcinoma cells (HeLa)] as well as normal liver cells (L02), except [Ru2 (η 6 ‐ p ‐cymene)2 ( p‐ bib)2 Cl2 ](NO3 )2 (10 ) (IC50 = 16.7 µm ), which had activity comparable with the anticancer drug cisplatin (IC50 = 15.8 µm ). Gel electrophoresis studies suggested that the complexes can interact with DNA and induce DNA condensation. Abstract : A series of 26‐membered Ru II 2 metallamacrocycles containing 1‐{3‐[(1 H ‐imidazol‐1‐yl)methyl]benzyl}‐1 H ‐imidazole ( m ‐bib) and 1‐{4‐[(1 H ‐imidazol‐1‐yl)methyl]benzyl}‐1 H ‐imidazole ( p ‐bib) ligands have been synthesized and characterized. One complex, [Ru2 (η 6 ‐ p ‐cymene)2 ( p‐ bib)2 Cl2 ](NO3 )2 (10 ), had activity comparable (IC50 = 16.7 µm ) with the anticancer drug cisplatin (IC50 = 15.8 µm ).