Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging. Issue 9 (21st March 2017)

• Record Type: Journal Article
• Authors: Korenchan, D. E.; Taglang, C.; von Morze, C.; Blecha, J. E.; Gordon, J. W.; Sriram, R.; Larson, P. E. Z.; Vigneron, D. B.; VanBrocklin, H. F.; Kurhanewicz, J.; Wilson, D. M.; Flavell, R. R.
• Is Part Of: Analyst. Volume 142:Issue 9(2017)
• Page Start: 1429
• Page End: 1433
• Publication Date: 2017-03-21
• Subjects: Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1039/c7an00076f
• Languages: English
• ISSNs: 0003-2654

Abstract

Abstract : Hyperpolarized [2- 13 C, D10 ]diethylmalonic acid demonstrates long-lived signal enhancements for high-accuracy pH imaging via 13 C MR spectroscopic imaging. Abstract : Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2- 13 C, D10 ]diethylmalonic acid, which exhibits a large pH-dependent 13 C chemical shift over the physiological range. We demonstrate that co-polarization with [1- 13 C, D9 ] tert -butanol accurately measures pH via 13 C NMR and magnetic resonance spectroscopic imaging in phantoms.