Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex. Issue 37 (25th April 2017)
- Record Type:
- Journal Article
- Title:
- Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex. Issue 37 (25th April 2017)
- Main Title:
- Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex
- Authors:
- Evans, Lindsay E.
Jones, Keith
Cheeseman, Matthew D. - Abstract:
- Abstract : A non-nucleotide FP-probe was designed to study the mechanism of action and druggability of the secondary HSP70/BAG1 complex. Abstract : Proteins typically carry out their biological functions as multi-protein complexes, which can significantly affect the affinity of small-molecule inhibitors. HSP70 is an important target in oncology, so to study its chemical biology and the drug discovery potential of the HSP70/BAG1 complex, we designed a high-affinity non-nucleotide fluorescence polarisation probe.
- Is Part Of:
- Chemical communications. Volume 53:Issue 37(2017)
- Journal:
- Chemical communications
- Issue:
- Volume 53:Issue 37(2017)
- Issue Display:
- Volume 53, Issue 37 (2017)
- Year:
- 2017
- Volume:
- 53
- Issue:
- 37
- Issue Sort Value:
- 2017-0053-0037-0000
- Page Start:
- 5167
- Page End:
- 5170
- Publication Date:
- 2017-04-25
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c7cc01376k ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 39.xml