Inducible epitope imprinting: 'generating' the required binding site in membrane receptors for targeted drug delivery. Issue 17 (19th April 2017)

• Record Type: Journal Article
• Authors: Liu, Sha; Bi, Qiuyan; Long, Yingying; Li, Zhuoxuan; Bhattacharyya, Sanjib; Li, Chong
• Is Part Of: Nanoscale. Volume 9:Issue 17(2017)
• Page Start: 5394
• Page End: 5397
• Publication Date: 2017-04-19
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c6nr09449j
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : The imprinted polymeric nanoparticles induce the flexible domain of a folate receptor into a conformationally rigid binding site. Abstract : We report an inducible epitope imprinting strategy that as a template, a flexible peptide chain can have a disordered-to-ordered conformational change by suitable inducement through a molecular imprinting procedure, and the formed nanoparticles can, in turn, remold the original peptide into the expected conformation and specifically bind to the corresponding protein.