Poly(propylene imine) dendrimer-grafted nanocrystalline cellulose: Doxorubicin loading and release behavior. (19th May 2017)

• Record Type: Journal Article
• Authors: Golshan, Marzieh; Salami-Kalajahi, Mehdi; Roghani-Mamaqani, Hossein; Mohammadi, Maryam
• Is Part Of: Polymer. Volume 117(2017)
• Page Start: 287
• Page End: 294
• Publication Date: 2017-05-19
• Subjects: Nanocrystalline cellulose -- Poly(propylene imine) dendrimer -- Folic acid -- Bioconjugation -- Drug release kinetics; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; 547.7
• DOI: 10.1016/j.polymer.2017.04.047
• Languages: English
• ISSNs: 0032-3861

Abstract

Abstract: 4 th -generation poly(propylene imine) (PPI)-grafted nanocrystalline cellulose (NCC) is prepared via iterative Michael addition of acrylonitrile onto amine-functionalized NCC as initial core and homogeneous hydrogenation of nitrile groups to primary amines. Successful grafting of dendrimers onto NCCs is confirmed by TEM, FT-IR, XPS, TGA and elemental analyses. Also, peripheral primary amines of dendrimer-grafted NCCs are conjugated with folic acid (FA) to investigate bioconjugation effect on drug release behavior of nanostructures. FA-conjugated and nonconjugated nanostructures are loaded with DOX and exposed to environments with different pH values to examine release behavior. Also, drug release kinetics is studied by fitting of experimental data with release models. At different pH values, nonconjugated nanostructures show higher cumulative drug release than FA-conjugated systems while loading content was higher for conjugated systems. Drug release from nonconjugated nanostructures is modeled using Korsmeyer-Peppas model that describes release from polymeric matrix. However, in conjugated system, Higuchi model is the best one due to the better solubility of DOX in release media than cavities of grafted dendrimers. Graphical abstract: Highlights: PPI-dendrimer-grafted NCC nanostructures are successfully prepared. Effect of bioconjugation by folic acid on DOX release is investigated. DOX release kinetics from nanostructures is studied by mathematical models. Folic acid bioconjugation changed the mechanism of drug release.