3-2-06. Somatosensory Evoked Potentials (SEPs) in Vitamin B12 deficiency. Issue 6 (June 2017)

• Record Type: Journal Article
• Authors: Hatamoto, Daisuke; Hatanaka, Yuki; Sakurai, Yasuhisa; Sugimoto, Izumi; Yamamoto, Jumpei; Nishiyama, Kyohei; Hokkoku, Keiichi; Ohkuma, Hidehiko; Chiba, Takashi; Kanbayashi, Takamichi; Kamiya, Hisao; Miyaji, Yosuke; Kawamura, Yasuomi; Ogawa, Go; Tsukamoto, Hiroshi; Sonoo, Masahiro
• Is Part Of: Clinical neurophysiology. Volume 128:Issue 6(2017:Jun.)
• Page Start: e168
• Publication Date: 2017-06
• Subjects: Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2017.03.025
• Languages: English
• ISSNs: 1388-2457

Abstract

Abstract: Vitamin B12 deficiency mainly affects the dorsal column. In this study, we investigated which part of the sensory pathway is affected in vitamin B12 deficiency using NCS and SEPs. We retrospectively reviewed EMG database of Teikyo University and Mitsui Memorial Hospital from 2008 to 2016, and enrolled patients who presented with sensory symptoms and/or gait disturbance, and whose serum B12 level was below 170 ng/ml. Enrolled were 17 patients. Spinal MRI demonstrated abnormalities in 4/17. NCS was abnormal in 3/15 patients for the sural nerve and in 5/12 patients for the median nerve. When NCS and peripheral segments of the SEPs were combined, conduction delay was detected in 12/15 patients for the lower limb and 8/13 patients for the upper limb. Delay of the central conduction was rarer, 3/15 patients in tibial SEPs. N9o to P13/14o segment in median SEPs was abnormal in 4/8 patients, although this is a mixture of the peripheral and central conductions. Vitamin B12 deficiency patients showed abnormalities of the peripheral nerve conduction more frequently than those of the central conduction. SEPs are useful in localizing the lesion along the sensory pathway, not only for CCT but for peripheral conduction.