Wound healing in cutaneous leishmaniasis: A double edged sword of IL-10 and TGF-β. (April 2017)

• Record Type: Journal Article
• Authors: Abdoli, Amir; Maspi, Nahid; Ghaffarifar, Fatemeh
• Is Part Of: Comparative immunology, microbiology and infectious diseases. Volume 51(2017)
• Page Start: 15
• Page End: 26
• Publication Date: 2017-04
• Subjects: Wound healing -- Leishmania -- Cutaneous leishmaniasis -- IL-10 -- TGF-β; Communicable diseases in animals -- Periodicals; Veterinary immunology -- Periodicals; Veterinary microbiology -- Periodicals; Immunology -- Periodicals; Microbiology -- Periodicals; Communicable diseases -- Periodicals; Communicable Diseases -- immunology -- Periodicals; Communicable Diseases -- veterinary -- Periodicals; Allergy and Immunology -- Periodicals; Microbiology -- Periodicals; Veterinary Medicine -- Periodicals; Immunologie -- Périodiques; Microbiologie -- Périodiques; Maladies infectieuses -- Périodiques; Communicable diseases; Immunology; Microbiology; Electronic journals; Periodicals; 636.08969
• DOI: 10.1016/j.cimid.2017.02.001
• Languages: English
• ISSNs: 0147-9571

Abstract

Highlights: IL-10 and TGF-β accelerate the physiological wound healing process. IL-10 and TGF-β control immunopathology caused by proinflammatory cytokines. IL-10 and TGF-β suppress immune responses in cutaneous leishmaniasis. IL-10 and TGF-β are responsible for parasite persistence in cutaneous leishmaniasis. Abstract: Immune responses have a crucial role during the wound healing process in cutaneous leishmaniasis (CL). However, there are several paradoxes in immunity against CL. On the one hand, regulatory cytokines interleukin (IL)-10 and transforming growth factor beta (TGF-β) increase susceptibility to CL through suppression of several proinflammatory cytokines that require for defense against CL. On the other hand, these cytokines play a pivotal role in the acceleration of wound healing process. This review discusses about the dual role of IL-10 and TGF-β during the wound healing process and immunity against CL to offer a new insight about wound healing in CL.