Acute intestinal damage following severe burn correlates with the development of multiple organ dysfunction syndrome: A prospective cohort study. Issue 4 (June 2017)

• Record Type: Journal Article
• Authors: Osuka, Akinori; Kusuki, Hirofumi; Matsuura, Hiroshi; Shimizu, Kentaro; Ogura, Hiroshi; Ueyama, Masashi
• Is Part Of: Burns. Volume 43:Issue 4(2017)
• Page Start: 824
• Page End: 829
• Publication Date: 2017-06
• Subjects: ALT alanine aminotransferase -- AMY amylase -- APACHE Acute Physiology and Chronic Health Evaluation -- AST aspartate aminotransferase -- CK creatine kinase -- Cre creatinine -- Hct hematocrit -- I-FABP intestinal fatty acid binding protein -- LDH lactate dehydrogenase -- MODS multiple organ dysfunction syndrome -- SOFA Sequential Organ Failure Assessment -- TBSA total body surface area; Burn -- Intestinal damage -- Organ dysfunction; Burns and scalds -- Periodicals; 617.11
• DOI: 10.1016/j.burns.2016.10.015
• Languages: English
• ISSNs: 0305-4179

Abstract

Highlights: We assessed the relationship between intestinal damage and burn severity. Burn caused intestinal damage. The extent the damage correlated with the full-thickness burn size. The increase of intestinal damage was associated with the development of MODS. Abstract: Background: Severely burned patients occasionally suffer intestinal ischemia leading to a fatal outcome, and the gut is considered a "motor" driving the development of multiple organ failure. However, in clinical settings, it has been difficult to assess acute intestinal damage following burn and its consequence to patient outcome. Intestinal fatty acid binding protein (I-FABP) is a known biomarker for diagnosing intestinal ischemia/damage. This study aimed to assess the extent of intestinal damage using serial I-FABP measurements following severe burn and to clarify the association between intestinal damage and the development of organ dysfunctions. Methods: Patients aged >15 years old who suffered burn over 20% total body surface area (TBSA) were enrolled in this prospective cohort study. Patients with cardiac arrest on admission or who were transferred >24 h after injury were excluded. Patients with chemical burn were also excluded. Burn size and Acute Physiology and Chronic Health Evaluation II (APACHE II) score were recorded at the time of patient enrollment. I-FABP was measured on admission and at 1, 4, 7, 14, and 30 days following injury. Other biomarkers such as lactate, lactate dehydrogenase (LDH), creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase, amylase, and creatinine (Cre) were also measured at the same time points as I-FABP. We also evaluated the serial change in Sequential Organ Failure Assessment (SOFA) score. Results: The study included 32 patients. Serum I-FABP level on the day of admission was significantly increased in the patients compared with healthy controls. Increased I-FABP levels were normalized at 4 days after injury. The serum level of I-FABP on the day of admission correlated with %TBSA (III) and APACHE II score. A high I-FABP level on admission was associated with the subsequent development of multiple organ dysfunction. The increase in I-FABP level also correlated with increases of AST, LDH, and CK levels. Conclusions: Serum level of I-FABP on admission day does not correlate with burn size, but with the deep burn area. The gut might be a crucial target organ following severe burn, and gut damage could have an important role in the development of multiple organ dysfunction.