Exploring phosphatidylinositol 5-phosphate 4-kinase function. (January 2015)

• Record Type: Journal Article
• Authors: Bulley, Simon J.; Clarke, Jonathan H.; Droubi, Alaa; Giudici, Maria-Luisa; Irvine, Robin F.
• Is Part Of: Advances in biological regulation. Volume 57(2015)
• Page Start: 193
• Page End: 202
• Publication Date: 2015-01
• Subjects: Phosphatidylinositol -- Phosphatidylinositol 5-phosphate -- Phosphatidylinositol 5-Phosphate4-kinase -- Kinase -- Inositide; Cellular control mechanisms -- Periodicals; Biological control systems -- Periodicals; Molecular biology -- Periodicals; Periodicals; 571.74
• DOI: 10.1016/j.jbior.2014.09.007
• Languages: English
• ISSNs: 2212-4926

Abstract

Abstract: The family of phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) is emerging from a comparative backwater in inositide signalling into the mainstream, as is their substrate, phosphatidylinositol 5-phosphate (PI5P). Here we review some of the key questions about the PI5P4Ks, their localisation, interaction, and regulation and also we summarise our current understanding of how PI5P is synthesised and what its cellular functions might be. Finally, some of the evidence for the involvement of PI5P4Ks in pathology is discussed.